Brendan Lo

CS & Mathematics · University of Chicago · 2030

Computational biology and machine learning. Co-author on four 2026 papers — one in the Journal of Cell Biology, three at ICML workshops — written in high school.

Research
4 papers, 2026J. Cell Biol. · ICML ×3
Labs
4 positionsColumbia · NYU · Weill Cornell ×2
Engineering
20+ sites shippedclub of 70, co-founded
Now
Open to research and engineering internships
RésuméSelected research
ε
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H₀
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|B(x,ε)|
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Arrow keys change the filtration scale ε; hold Shift with the arrow keys to rotate the view. Drag to rotate, or drag vertically to change ε. The current ε and component count are listed in the figure.

Fig. 1 — Vietoris–Rips filtration of a synthetic cell-cycle manifold

2,400 points sampled on a noisy loop with one branch in R⁸, projected to R³ through the top three principal components. Edges enter as ε grows; H₀ is the exact component count, by union-find.

900 points on a noisy loop with one branch in R⁸, projected to R³. H₀ is exact, by union-find.

Selected research

2026Journal Article

Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.

Journal of Cell Biology

10.1083/jcb.202505134

…, Huang, W., Almeida, D., Lewarchik, C., Lo, B., Wu, Y., Gotthardt, M., …

2026Poster

A horizon-dependent intrinsic-dimension theory of scaling for biological forecasting.

HiLD Workshop, International Conference on Machine Learning (ICML)

Cheng, B., Jin, A., Zhang, J., Pemmaraju, A., Lo, B., Chang, J.

2026Poster

ERVNet: A three-module framework for predicting endogenous retrovirus reactivation, gene propagation, and immunogenicity.

FM4LS Workshop, International Conference on Machine Learning (ICML)

Cheng, B., Jin, A., Zhang, J., Lo, B., Pemmaraju, A., Chang, J.

2026Poster

PROTEUS: Predicting how post-translational modifications alter drug binding affinity.

FM4LS Workshop, International Conference on Machine Learning (ICML)

Cheng, B., Jin, A., Zhang, J., Pemmaraju, A., Chang, J., Lo, B.

Research positions

Summer 2026

Summer Research Intern — Blumberg Lab

Columbia UniversityNew York, NY

  • Applying Topological Data Analysis (TDA) to RNA-Seq annotation.

Summer 2026

Summer Research Intern — Shasha Lab

New York UniversityNew York, NY

  • Building an agentic AI workflow for a calorie-tracking application.

Summer 2025

Pediatrics Summer Research Intern — Heart Regeneration (Kühn & Liu Lab)

Weill Cornell Medical CollegeNew York, NY

  • Ran data analyses with Python, Fiji/ImageJ, and VBA to uncover calcium's role in cardiomyocyte proliferation.
  • Co-authored the resulting paper, published in the Journal of Cell Biology.

Summer 2024

Summer Research Intern — Epigenetics of Congenital Heart Disease (Long Lab)

Weill Cornell Medical CollegeNew York, NY

  • Performed PCR, Western blot, cloning, and RNA-seq analyses in R and Python to identify genes regulated by JARID2.
  • Investigated the role of the PRC2 complex in heart development and congenital heart disease.

Sep 2024 - Sep 2025

Independent Researcher

PRC2 Drug Discovery ProjectNew York, NY

  • Ran ML-based (Random Forest, Python, Schrödinger Maestro) virtual screening and GROMACS molecular dynamics simulations.
  • Repurposed drugs to inhibit the PRC2 protein complex as a target for cancer and congenital heart disease.

Engineering & leadership

Oct 2024 - Present

Co-President / Co-Founder

Web Development ClubGreat Neck, NY

  • Recruited and led full-stack projects with 70+ members using JavaScript, TypeScript, React.js, Supabase, and SQL.
  • Built and maintained 20+ websites for nonprofits, churches, businesses, and school clubs.

Jan 2024 - Present

Chief Technology Officer / Head of Newsletter

Kudos ConnectGreat Neck, NY

  • Led 15+ people to build the website and newsletter, growing a following of 7000+ students for volunteer opportunities.

Jan 2024 - Present

Board Member / App Leader

Programming ClubGreat Neck, NY

  • Taught 20+ students to code in AI/ML, Python, and Java.
  • Led 10+ students to build a school app for 1300+ students using Swift.

Sep 2024 - Present

Head Webmaster / Lead Programmer

FIRST Robotics Team 2638Great Neck, NY

  • Coded trajectory-generation algorithms and robot control, competing at the FIRST Robotics World Championship (2025).

Selected work

ReSource

Built as a full-stack Next.js app with PostgreSQL and Supabase, integrating Gemini API and Mapbox for real-time item recognition and location.

Next.js · TypeScript · Gemini API · Mapbox · PostgreSQL · Supabase

SATsaurus

Gamified SAT-prep platform delivering free, interactive practice to 1000+ students worldwide.

Next.js · Supabase · SQL · TailwindCSS

GNS Web Development Club

Co-founded and led a 70+ member community that built and maintained 20+ websites for nonprofits, churches, businesses, and school clubs.

React.js · Next.js · TypeScript · Supabase

Force Network

High-performance hosting hub for 100+ Minecraft servers and deployment solutions, serving secure nodes and bandwidth to 800+ users.

Node.js · Docker · MongoDB · Pterodactyl

Colophon

Expected May 2030

University of Chicago

B.S. Computer Science & Mathematics

June 2026

Great Neck South High School

High School Diploma

GPA 96.7 / 100 (unweighted) · SAT 1540 / 1600

AP Physics C, AP Calculus BC, AP Computer Science, AP English Literature, AP Spanish, AP Economics, Senior Seminar Research Honors.

Frontend

Next.js, React.js, TypeScript, JavaScript, HTML/CSS, TailwindCSS, Swift

Backend

Python, Java, C#, SQL, Node.js, Express.js, Supabase, MongoDB, Gemini API

Research

R, AI/ML, RNA-seq Analysis, Molecular Docking, Molecular Dynamics, GROMACS, Fiji/ImageJ, VBA