Brendan Lo

Software Engineer & Researcher studying Computer Science & Mathematics at UChicago.
Building scalable full-stack applications and advancing computational research
at the intersection of technology and science.

Frontend

Next.js

React.js

TypeScript

JavaScript

HTML/CSS

TailwindCSS

Swift

Backend

Python

Java

SQL

Node.js

Express.js

Supabase

MongoDB

Gemini API

Research & Science

AI/ML

RNA-seq Analysis

Molecular Docking

Molecular Dynamics

GROMACS

Fiji/ImageJ

VBA

Projects

Active work across full-stack, AI, and community tools.

ReSource

AI-powered marketplace that helps users donate, resell, or recycle unwanted items with AI image recognition and community mapping.

Next.jsTypeScriptGemini API

SATsaurus

Gamified SAT-prep platform delivering free, interactive practice to 1000+ students worldwide.

Next.jsSupabaseSQL

GNS Web Development Club

Co-founded and led a 70+ member community that built and maintained 20+ websites for nonprofits, churches, businesses, and school clubs.

React.jsNext.jsTypeScript

Force Network

High-performance hosting hub for 100+ Minecraft servers and deployment solutions, serving secure nodes and bandwidth to 800+ users.

Node.jsDockerMongoDB

Publications

Peer-reviewed research in machine learning and cell biology.

Journal ArticleJournal of Cell Biology · 2026

Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.

Liu, H., Ammanamanchi, N., Mich-Basso, J., Panama, B., Li, Y., Huang, W., Almeida, D., Lewarchik, C., Lo, B., Wu, Y., Gotthardt, M., Kotlikoff, M., Baehr, W., Rasmusson, R., Salama, G., & Kühn, B.

PosterHiLD Workshop, International Conference on Machine Learning (ICML) · 2026

A horizon-dependent intrinsic-dimension theory of scaling for biological forecasting.

Cheng, B., Jin, A., Zhang, J., Pemmaraju, A., Lo, B., & Chang, J.

PosterFM4LS Workshop, International Conference on Machine Learning (ICML) · 2026

ERVNet: A three-module framework for predicting endogenous retrovirus reactivation, gene propagation, and immunogenicity.

Cheng, B., Jin, A., Zhang, J., Lo, B., Pemmaraju, A., & Chang, J.

PosterFM4LS Workshop, International Conference on Machine Learning (ICML) · 2026

PROTEUS: Predicting how post-translational modifications alter drug binding affinity.

Cheng, B., Jin, A., Zhang, J., Pemmaraju, A., Chang, J., & Lo, B.

Experience

Research internships and engineering leadership.

Summer Research Intern — Blumberg Lab

Summer 2026

Columbia UniversityNew York, NY

Applying Topological Data Analysis (TDA) to RNA-Seq annotation.

Summer Research Intern — Shasha Lab

Summer 2026

New York UniversityNew York, NY

Building an agentic AI workflow for a calorie-tracking application.

Pediatrics Summer Research Intern — Heart Regeneration (Kühn & Liu Lab)

Summer 2025

Weill Cornell Medical CollegeNew York, NY

Ran data analyses with Python, Fiji/ImageJ, and VBA to uncover calcium's role in cardiomyocyte proliferation.
Co-authored the resulting paper, published in the Journal of Cell Biology.

Summer Research Intern — Epigenetics of Congenital Heart Disease (Long Lab)

Summer 2024

Weill Cornell Medical CollegeNew York, NY

Performed PCR, Western blot, cloning, and RNA-seq analyses in R and Python to identify genes regulated by JARID2.
Investigated the role of the PRC2 complex in heart development and congenital heart disease.

Co-President / Co-Founder

Oct 2024 - Present

Web Development ClubGreat Neck, NY

Recruited and led full-stack projects with 70+ members using JavaScript, TypeScript, React.js, Supabase, and SQL.
Built and maintained 20+ websites for nonprofits, churches, businesses, and school clubs.

Chief Technology Officer / Head of Newsletter

Jan 2024 - Present

Kudos ConnectGreat Neck, NY

Led 15+ people to build the website and newsletter, growing a following of 7000+ students for volunteer opportunities.

Board Member / App Leader

Jan 2024 - Present

Programming ClubGreat Neck, NY

Taught 20+ students to code in AI/ML, Python, and Java.
Led 10+ students to build a school app for 1300+ students using Swift.

Head Webmaster / Lead Programmer

Sep 2024 - Present

FIRST Robotics Team 2638Great Neck, NY

Coded trajectory-generation algorithms and robot control, competing at the FIRST Robotics World Championship (2025).

Independent Researcher

Sep 2024 - Sep 2025

PRC2 Drug Discovery ProjectNew York, NY

Ran ML-based (Random Forest, Python, Schrödinger Maestro) virtual screening and GROMACS molecular dynamics simulations.
Repurposed drugs to inhibit the PRC2 protein complex as a target for cancer and congenital heart disease.

Education

Academic background and coursework.

University of Chicago

Expected May 2030

B.S. Computer Science & MathematicsChicago, IL

Great Neck South High School

June 2026

High School DiplomaGreat Neck, NY

GPA 96.7 / 100 (unweighted) · SAT 1540 / 1600
AP Physics C, AP Calculus BC, AP Computer Science, AP English Literature, AP Spanish, AP Economics, Senior Seminar Research Honors.